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To be sedated when dining with the Queen means that you were face down in the bread pudding and drooling onto the tablecloth.

The medical sense of the word is to be tranquilized, either to calm your nerves after a shock or in preparation for surgery.

According to a Dallas Morning News investigation in 2015, a dental patient dies nearly every other day in the United States.

Sedatives encompass a wide variety of drugs with different mechanisms of action that can induce depression of the central nervous system (CNS).

Of course, in reality (as usual with anything equine! For those who haven’t seen it before, a sedated horse doesn’t lie down, but their head gets lower and lower, and they may require something to lean on to help them balance.

It’s also important to remember that a sedated horse CAN still kick – they’re just much less likely to do so!

In the first part of the 20th century, the pharmacotherapy of anxiety and insomnia relied on barbiturates, which were replaced with benzodiazepines as drugs of choice in the second part of the previous century.

more sedating-26more sedating-2

Although it isn't completely understood, it is believed that its effectiveness in the treatment of schizophrenia, bipolar depression, and bipolar manias is due to its work against the dopamine and serotonin receptors.

Wendy Sue Swanson of Seattle Children's Hospital and a spokesperson from the influential pediatricians group is sounding the alarm about sedating children for oral surgery.

"If we can prevent one more child from an adverse event or a death, we’ve got to try,” Swanson told NBC News. The state boards that oversee dental practice in America usually don’t make that kind of information public.

At very low doses (25-100 mg), quetiapine acts primarily as a histamine receptor blocker (antihistamine) and alpha-adrenergic blocker.

Antihistamines, like some allergy medicines, are known to have sedative effects.

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